Endosomal cholesterol trafficking: protein factors at a glance
نویسندگان
چکیده
منابع مشابه
Endosomal cholesterol trafficking: protein factors at a glance.
The delivery of low-density lipoprotein-derived cholesterol (LDL-C) from endosomal compartments to the plasma membrane and the endoplasmic reticulum (ER) is an important yet poorly understood cellular process. Niemann-Pick C1 (NPC1), a multi-pass integral membrane protein on the limiting membranes of late endosomes (LE)/lysosomes (Ly), is known to insert lumenal LDL-C to the limiting membrane o...
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Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...
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Integrins are heterodimeric transmembrane receptors for extracellular matrix (ECM) components and they link the intracellular actin cytoskeleton to the cellular environment (Humphries et al., 2006; Hynes, 2002). The aand b-subunits of integrin heterodimers are type I membrane proteins that typically have a large extracellular domain and a short intracellular tail. Through different combinations...
متن کاملPeptide and Protein Delivery at a Glance
Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...
متن کاملLate Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
BACKGROUND Pathological accumulation of cholesterol in late endosomes is observed in lysosomal storage diseases such as Niemann-Pick type C. We here analyzed the effects of cholesterol accumulation in NPC cells, or as phenocopied by the drug U18666A, on late endosomes membrane organization and dynamics. METHODOLOGY/PRINCIPAL FINDINGS Cholesterol accumulation did not lead to an increase in the...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2012
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gms095